HDAC3
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Official Full Name
histone deacetylase 3 -
Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control. -
Synonyms
HDAC3;histone deacetylase 3;HD3;RPD3;RPD3 2;SMAP45;RPD3-2
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Insect Cells
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- S.frugiperda
- Sf21 Insect Cell
- HEK293
- HEK293T
- Insect cell
- In Vitro Cell Free System
- GST
- His&GST
- Flag
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
HDAC3 involved in several pathways and played different roles in them. We selected most pathways HDAC3 participated on our site, such as Thyroid hormone signaling pathway,Alcoholism,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | HLA-F,HPN,YWHAB,VAC14,CDK1,RBL1,CCNA1,GTF2A1L,CREB3L2,ACTN1 |
| Thyroid hormone signaling pathway | PLCD4,AKT2,PLCD1,BMP4,STAT1,CCND1,ATP1B4,PIK3R1,PLCG2,ATP2A2 |
| Alcoholism | BDNF,MAPK3,HDAC8,GRIN2C,HIST1H4J,DDC,CREB3L3,CREB3,GNG8,HIST1H4L |
Protein Function
HDAC3 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),NF-kappaB binding,chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC3 itself. We selected most functions HDAC3 had, and list some proteins which have the same functions with HDAC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | ZNF593,HOMEZB,ZNF136,HDAC9,RUNX1T1,TBL1Y,CREG1,TRIM22,NCOR1,HSBP1 |
| NF-kappaB binding | RELA,NFKBIA,CPNE1,HDAC2,EP300,COMMD6,TAF4B,SNAI1A,BRMS1,HIF1AN |
| histone deacetylase activity | HDAC2,SIRT2,HDAC11,HDAC10,SIRT1,HDAC1,HDAC9B,HDAC6,HDAC4,ATXN3L |
| protein binding | PTPN6,AP5Z1,PLAT,GTPBP10,PPP1R15B,KIF27,KLK8,AGPS,SNX3,CBX4 |
| enzyme binding | C6orf211,DYM,GNB2L1,PLSCR1,HSPA6,N4BP2L2,HSPA1A,HIF1A,ATG3,PEX7 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC7,HDAC7A,HDAC5,HDAC11,HDAC2,HDAC10,HDAC9B,HDAC6,HDAC9,HDAC8 |
| chromatin binding | DLX2,ASH1L,MCMBP,NONO,TAL1,NFIA,DNAJC2,TDRD3,BCL6,ZEB1 |
| transcription factor binding | FLNA,CTBP1,NLRP3,PURB,SUMO1,SOST,TFAP2A,PDCD11,MYOD1,KCNA3 |
| protein deacetylase activity | HDAC2,SIRT1,HDAC4,SIRT2,HDAC10,HDAC9,HDAC1,HDAC5,SIN3A |
Interacting Protein
HDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC3.
NCOR2;NCOR1;KDM1A;L3MBTL2;MAGEA2
HDAC3 Related Signal Pathway
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References
- Hoeksema, MA; Gijbels, MJJ; et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO MOLECULAR MEDICINE 6:1124-1132(2014).
- Svegliati, S; Marrone, G; et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. SCIENCE SIGNALING 7:-(2014).
