Active Recombinant Human Histone Deacetylase 3, His GST-tagged

• Cat.No.: HDAC3-394H
• Product Overview: Full Length Human HDAC3– Class I, 53kD with his His & GST tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
• Purity: Purified, active enzyme.
• Purification Procedure: Ni2+ Affinity Column & Glutathione
• Activity: 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
• Stability/Shelf-life: >6 months from date of shipment
• Buffer Composition: 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
• Storage: –80°C
• Full Length: Full L.

Gene Information

• Gene Name: HDAC3 histone deacetylase 3 [ Homo sapiens ]
• Synonyms: HDAC3; RPD3; HD3; RPD3-2; histone deacetylase 3; EC 3.5.1.98; SMAP45.
• Gene ID: 8841
• mRNA Refseq: NM_003883
• Protein Refseq: NP_003874
• MIM: 605166
• UniProt ID: O15379
• Chromosome Location: 5q31
• Pathway: Signalling by NGF
• Function: DNA binding; histone deacetylase activity; hydrolase activity; transcription factor binding