Recombinant Human HDAC3, His-tagged

Cat.No. : HDAC3-390H
Product Overview : Recombinant Human HDAC3 was expressed in insect cell.
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Species : Human
Source : Insect Cells
Tag : His
Protein Length : 428 amino acids
Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Form : 103 μg/μl in 50 mM Tris, pH 8.0, 138 mM NaCl and 10% glycerol.
Specific activity : >1 U/µg.
Molecular Mass : 49 kDa
Purity : ~50% by SDS-PAGE.
Applications : Study HDAC3 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis.
Gene Name HDAC3 histone deacetylase 3 [ Homo sapiens (human) ]
Official Symbol HDAC3
Synonyms HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; EC 3.5.1.98
Gene ID 8841
mRNA Refseq NM_003883
Protein Refseq NP_003874
MIM 605166
UniProt ID O15379
Chromosome Location 5q31
Pathway Alcoholism; BMAL1:CLOCK/NPAS2 Activates Circadian Expression; Cell cycle; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Function chromatin DNA binding; enzyme binding; histone deacetylase activity; protein binding

Not For Human Consumption!

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