Recombinant Human HDAC3, His-tagged
Cat.No. : | HDAC3-390H |
Product Overview : | Recombinant Human HDAC3 was expressed in insect cell. |
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Species : | Human |
Source : | Insect Cells |
Tag : | His |
Protein Length : | 428 amino acids |
Description : | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
Form : | 103 μg/μl in 50 mM Tris, pH 8.0, 138 mM NaCl and 10% glycerol. |
Specific activity : | >1 U/µg. |
Molecular Mass : | 49 kDa |
Purity : | ~50% by SDS-PAGE. |
Applications : | Study HDAC3 kinetics and inhibitor sensitivity and also the effect of the enzyme in transcriptional regulation, cell cycle progression, and oncogenesis. |
Gene Name | HDAC3 histone deacetylase 3 [ Homo sapiens (human) ] |
Official Symbol | HDAC3 |
Synonyms | HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; histone deacetylase 3; SMAP45; EC 3.5.1.98 |
Gene ID | 8841 |
mRNA Refseq | NM_003883 |
Protein Refseq | NP_003874 |
MIM | 605166 |
UniProt ID | O15379 |
Chromosome Location | 5q31 |
Pathway | Alcoholism; BMAL1:CLOCK/NPAS2 Activates Circadian Expression; Cell cycle; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
Function | chromatin DNA binding; enzyme binding; histone deacetylase activity; protein binding |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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