HDAC1
-
Official Full Name
histone deacetylase 1 -
Overview
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] -
Synonyms
HDAC1;histone deacetylase 1;HD1;RPD3;GON-10;RPD3L1;reduced potassium dependency, yeast homolog-like 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Insect cells
- Mammalian Cell
- Wheat Germ
- Hi-5 Insect Cell
- HEK293
- Insect cell
- Mammalian cells
- Baculovirus
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- His
- C-Flag,C-His
- Non
- His&Flag
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
HDAC1 involved in several pathways and played different roles in them. We selected most pathways HDAC1 participated on our site, such as Cell cycle,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | CCND1,TGFB3,RB1,TP53,ARAF,CTBP2,CBLB,HRAS,MAPK3,IKBKG |
| Pathways in cancer | GNG10,PRKACG,CTNNA3,PIAS2,FOS,BIRC7,CBL,LAMB3,Ar,FZD10 |
| Cell cycle | WRAP53,SYCE1,DCTN2,E2F3,CDC14B,KIF2A,TERF2,GOLGA2,MAU2,CTDNEP1A |
| Thyroid hormone signaling pathway | NCOR1,MTOR,PLCG1,HDAC3,MED12L,NOTCH1,PRKACG,FOXO1,PIK3R1,ATP1B3 |
| Epstein-Barr virus infection | YWHAB,CCNA1,CR2,HLA-C,MAP3K7,TBPL2,YWHAH,CCNA2,PSMD11,AKT1 |
| MicroRNAs in cancer | RPS6KA5,CYP24A1,Pdgfa&Pdgfb,BRCA1,PDGFB,PDGFRB,ROCK1,DNMT3B,CCNE1,CD44 |
| Alcoholism | HIST1H3H,HIST1H4K,RAF1,HIST3H2BB-PS,HIST1H2BG,HIST1H2AJ,PRKACA,HIST1H3D,HIST1H2BO,CAMKK2 |
| Notch signaling pathway | MARK2,DTX4,TUBB3,ADAM17A,NCOR2,NUMBL,DNER,DLL3,DTX1,PSENEN |
| Viral carcinogenesis | IRF3,TBPL2,HIST1H2BF,MAPK3,HIST1H4M,HIST1H4K,CREB3L2,EIF2AK2,YWHAH,NRAS |
Protein Function
HDAC1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),NF-kappaB binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC1 itself. We selected most functions HDAC1 had, and list some proteins which have the same functions with HDAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC11,HDAC8,HDAC6,HDAC9,HDAC4,HDAC5,HDAC3,HDAC7A,HDAC2,HDAC7 |
| deacetylase activity | AADAC,NDST3,MAPK1IP1L,HDAC2,C6orf130,MACROD2,NDST1,MACROD1,NDST4,SIRT1 |
| NF-kappaB binding | NFKBIA,CPNE1,HDAC3,CDKN2A,GSK3B,DNAJA3,MTDH,RELA,RNF25,BCL10 |
| transcription factor binding | MYBBP1A,CEBPG,ESR1,PPID,IFT172,RORA,FOXO1,GTF2A2,PSMD4,REST |
| repressing transcription factor binding | HDAC4,HDAC7,TBP,EIF4E,PRDM5,GMNN,TCF3,CTNNB1,TLE4,SKI |
| RNA polymerase II repressing transcription factor binding | BBS4,TBX5A,MTA2,STAT3,RBBP8,TTC8,MIXL1,TCF7L2,GSC,TCERG1 |
| protein N-terminus binding | FEZ1,KCNIP1,APTX,CHMP6,PEX14,DCTN4,KCNB1,HAX1,RBPJ,SNF8 |
| RNA polymerase II transcription corepressor activity | ELANE,TCERG1,CTBP1,BEND6,TLE1,UXT,TXLNB,RERE,URI1,TFAP2B |
| protein deacetylase activity | HDAC10,HDAC2,SIRT2,HDAC3,HDAC4,HDAC9,SIRT1,HDAC5,SIN3A |
Interacting Protein
HDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC1.
HDAC2;MTA2;RBBP7
HDAC1 Related Signal Pathway
Resources
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References
- Zou, JY; Crews, FT; et al. Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling. PLOS ONE 9:-(2014).
- Kim, JH; Jee, BC; et al. Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men. YONSEI MEDICAL JOURNAL 55:1333-1340(2014).
