Recombinant Human Histone Deacetylase 1, His-FLAG Tagged

• Cat.No.: HDAC1-374H
• Product Overview: Recombinant Humanfull-length HDAC1 with C-terminal His-FLAG Tagged.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag&His
• Description: HDAC1belongs to the Histone Deacetylase/acuc/apha family and is a component of theHistone Deacetylase complex. HDAC1 interacts with Retinoblastomatumor-suppressor protein (Rb) and this complex is a key element in thecontrol of cell proliferation and differentiation. Together withMetastasis-Associated Protein-2, it deacetylates p53 and modulates its effecton cell growth and apoptosis.
• Form: Liquid in 25 mMTris-HCl, pH 8.0 + 130 mM NaCl + 0.05% Tween-20 + 10% Glycerol.
• Molecular Weight: 56 kDa
• Applications: Enzyme kinetics; Screeninginhibitors; Selectivity profiling.The optimal concentration should bedetermined by the user for each specific application.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: HDAC1

Gene Information

• Gene Name: HDAC1 histone deacetylase 1 [ Homosapiens ]
• Synonyms: HDAC1; histone deacetylase 1; DKFZp686H12203;GON-10; HD1; RPD3; RPD3L1; OTTHUMP00000008745; reduced potassium dependency,yeast homolog-like 1; DKFZp686H12203; EC 3.5.1.98
• Gene ID: 3065
• mRNA Refseq: NM_004964
• Protein Refseq: NP_004955
• MIM: 601241
• UniProt ID: Q13547
• Chromosome Location: 1p34
• Pathway: Androgen Receptor Signaling Pathway; CellCycle; Chronic myeloid leukemia; Delta-Notch Signaling Pathway; E2Ftranscription factor network; EGFR1 Signaling Pathway; Energy Metabolism; G0and Early G1; Glucocorticoid receptor regulatory network; Hedgehog signalingevents mediated by Gli proteins; Hemostasis; Huntington"s disease; IL-6Signaling Pathway; Mitotic G1-G1/S phases; Notch signaling pathway
• Function: enzyme binding; histonedeacetylase activity; hydrolase activity; identical protein binding;transcription activator activity; transcription factor activity;transcription factor binding; transcription factor binding