Recombinant Human HDAC1
| Cat.No. : | HDAC1-29190TH |
| Product Overview : | Recombinant full length Human HDAC1 with C terminal His and Flag tags, 56kDa. |
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| Description : | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. |
| Protein length : | 482 amino acids |
| Conjugation : | FLAG,His |
| Molecular Weight : | 56.000kDa |
| Source : | Baculovirus |
| Tissue specificity : | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
| Biological activity : | Specific Activity: 390 pmol/min/μg. |
| Form : | Liquid |
| Purity : | by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 130mM Sodium chloride, pH 8.0 |
| Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the histone deacetylase family. HD type 1 subfamily. |
| Tag : | His&Flag |
| Gene Name | HDAC1 histone deacetylase 1 [ Homo sapiens ] |
| Official Symbol | HDAC1 |
| Synonyms | HDAC1; histone deacetylase 1; RPD3L1; GON 10; HD1; |
| Gene ID | 3065 |
| mRNA Refseq | NM_004964 |
| Protein Refseq | NP_004955 |
| MIM | 601241 |
| Uniprot ID | Q13547 |
| Chromosome Location | 1p34 |
| Pathway | Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; |
| Function | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); RNA polymerase II transcription corepressor activity; activating trans; |
Not For Human Consumption!
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