EIF2AK4

  • Official Full Name

    eukaryotic translation initiation factor 2 alpha kinase 4

  • Overview

    EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation;factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et;al., 1999 (PubMed 10504407)).

  • Synonyms

    EIF2AK4;eukaryotic translation initiation factor 2 alpha kinase 4;eukaryotic translation initiation factor 2-alpha kinase 4;GCN2;KIAA1338;GCN2-like protein;GCN2 eIF2alpha kinase

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Insect Cell
  • Wheat Germ
  • Insect Cell
  • Mammalian Cell
  • HEK293
  • Insect (sf21)
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF2AK4-3346H Recombinant Human EIF2AK4 protein, His-tagged E.coli Human His
EIF2AK4-1011H Recombinant Human Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4, GST-tagged Sf9 Insect Cell Human GST 192-1024 a.a.
EIF2AK4-28160TH Recombinant Human EIF2AK4 Wheat Germ Human Non 100 amino acids
EIF2AK4-3152H Active Recombinant Human EIF2AK4 Protein, GST-tagged Insect Cell Human GST
EIF2AK4-3153H Recombinant Human EIF2AK4 Protein, GST-tagged Wheat Germ Human GST
EIF2AK4-5078M Recombinant Mouse EIF2AK4 Protein Mammalian Cell Mouse His
EIF2AK4-6672HCL Recombinant Human EIF2AK4 293 Cell Lysate HEK293 Human Non
EIF2AK4-1414H Recombinant Human EIF2AK4 Protein, His-tagged E.coli Human His Val296-Ile539
EIF2AK4-2310HF Active Recombinant Full Length Human EIF2AK4 Protein, DDK-tagged, Biotinylated Insect (sf21) Human Flag Full L. 1-1649(end)
EIF2AK4-2700M Recombinant Mouse EIF2AK4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EIF2AK4-2700M-B Recombinant Mouse EIF2AK4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EIF2AK4-3747HF Active Recombinant Full Length Human EIF2AK4 Protein, GST-tagged Insect (sf21) Human GST Full L. 1-1649(end)
EIF2AK4-4488HF Recombinant Full Length Human EIF2AK4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 91 amino acids

    Involved Pathway

    EIF2AK4 involved in several pathways and played different roles in them. We selected most pathways EIF2AK4 participated on our site, such as Protein processing in endoplasmic reticulum,Hepatitis C,Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection POLR2D,SHFM1,POLR2K,MDM2,PIK3CD,HSPA6,NUP214,SND1,POLR2B,MAP2K4
    Measles STAT1,IFNA12,TYK2,PIK3R3,NFKBIA,PIK3R5,PIK3CD,CCNE2,CD209B,TLR4
    Protein processing in endoplasmic reticulum DNAJC3A,DNAJB1B,DNAJC5AA,RPN2,ERO1L,RAD23AB,PDIA6,CAPN1,SELS,MAPK8B
    Herpes simplex infection SOCS3B,IRF3,IFIH1,SRSF9,SRSF1B,IKBKE,FASLG,TRAF6,PVRL1,HLA-DQB1
    Hepatitis C IRF3,TRAF6,SOS1,RXRA,IFNA12,IFNA4,IFNA2,IFNA21,STAT2,AKT2
    Influenza A BCL2L2-PABPN1,HLA-DMB,IFNA5,FDPS,HLA-DRB3,NXF2,PIK3R3,IL12B,TYK2,BLB1

    Protein Function

    EIF2AK4 has several biochemical functions, for example, ATP binding,eukaryotic translation initiation factor 2alpha kinase activity,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK4 itself. We selected most functions EIF2AK4 had, and list some proteins which have the same functions with EIF2AK4. You can find most of the proteins on our site.

    Function Related Protein
    tRNA binding FARSA,MADD,ALKBH8,TYW5,SEPSECS,AARS,IFIT5,AIMP1,EARS2,FDXACB1
    eukaryotic translation initiation factor 2alpha kinase activity EIF2AK2,ALPK2,EIF2AK1,EIF2AK3
    ATP binding ABCD3A,PGS1,INSRA,PKDCC,RAD17,UBE2M,EPHB4A,TTLL12,MOV10B.2,PANK1
    protein serine/threonine kinase activity NLK,CAMK2A,STK35L,SBK1,DAPK1,C9orf96,PRKCA,SMOK3A,ROCK2B,RPS6KA5

    Interacting Protein

    EIF2AK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK4.

    a8k1f4_human;b4dyc6_human;BAG2;STIP1;MLF1;USP46;PSMD2;CDC37;q53fc7_human;HSP90AB1;NUDCD3;q96be0_human;AARSD1;CACYBP;EWSR1;linkable pd173955 analogue;bosutinib;imatinib;ARRB2

    Resources

    References

    • Querec, TD; Akondy, RS; et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. NATURE IMMUNOLOGY 10:116-125(2009).
    • Skalnikova, H; Vodicka, P; et al. Protein signaling pathways in differentiation of neural stem cells. PROTEOMICS 8:4547-4559(2008).

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