Cfd
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Official Full Name
complement factor D (adipsin) -
Overview
Complement Factor D (CFD) is a 253 amino acid secreted protein that belongs to the peptidase S1 family. It contains 1 peptidase S1 domain. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement Factor D catalyzes the selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. -
Synonyms
ADIPSIN;ADN;DF;PFD;C3 convertase activator;D component of complement (adipsin);complement factor D;complement factor D preproprotein;properdin factor D
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Rhesus macaque/Cynomolgus
- E.coli
- HEK293
- Mammalian cells
- Human Serum
- Mammalian Cell
- Wheat Germ
- Insect Cell
- Human Cell
- Yeast
- In Vitro Cell Free System
- HEK293T
- His
- Fc
- Non
- His&Myc
- His&GST
- GST
- His&Fc&Avi
- His&Avi
- Myc&DDK
Involved Pathway
Cfd involved in several pathways and played different roles in them. We selected most pathways Cfd participated on our site, such as Adipogenesis,Alternative complement activation,Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cfd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement cascade | HBL3,C1rb,FCN3,MASP2,CFHL2,BFB,IgG3,FCN2,CFHL3,GZMM |
| Innate Immune System | CFHL3,C1rb,CLEC4A,SIGIRR,CASP4,TANK,WIPF2,HERC5,DEFB129,ACTR2B |
| Alternative complement activation | BFB,GZMM |
| Adipogenesis | EGR2B,CELF1,GADD45A,GATA2,CTNNB1,EBF1,CNTFR,CEBPD,GATA2A,CISD1 |
| Hemostasis | CAP1,EHD1,DGKB,KIF11,KIFAP3,HMG20B,KIF3C,ANXA2,KIF26A,CEACAM1 |
| Initial triggering of complement | IgG3,GZMM,FCN3,HBL3,FCN1,C1rb,MASP2,CRP,BFB,FCN2 |
| Immune System | IFIT8,ISG20,EIF4G2A,FCGR1B,KLC3,MASP2,ASB3,CD96,NCKAP1,RNF220 |
| Complement and coagulation cascades | CD46,C8B,C5AR1,C1S,SERPINA1D,F5,C4BP,C7,F10,PLAUR |
Protein Function
Cfd has several biochemical functions, for example, serine-type endopeptidase activity,serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cfd itself. We selected most functions Cfd had, and list some proteins which have the same functions with Cfd. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type peptidase activity | C1rb,ENDOU,MCPT1,PRSS59.2,Gzmg,SEC11A,PRSS30,CMA1,HTRA1A,DPP6B |
| serine-type endopeptidase activity | PROZ,PARLA,KLK1B8,C1R,HTRA3A,PCSK2,PRSS28,TMPRSS7,MASP2,CTSH |
Interacting Protein
Cfd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cfd here. Most of them are supplied by our site. Hope this information will be useful for your research of Cfd.
yvrG;ALB
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References
- Yang, AS; Chuang, FC; et al. A high-performance micromixer using three-dimensional Tesla structures for bio-applications. CHEMICAL ENGINEERING JOURNAL 263:444-451(2015).
- Johnson, C; Natarajan, V; et al. Verification of energy dissipation rate scalability in pilot and production scale bioreactors using computational fluid dynamics. BIOTECHNOLOGY PROGRESS 30:760-764(2014).
