Ccl4
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Official Full Name
chemokine (C-C motif) ligand 4 -
Overview
CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta. -
Synonyms
Ccl4;chemokine (C-C motif) ligand 4;MIP-1b;MIP 1 beta;Secreted protein G 26;ACT 2;ACT-2;ACT2;AT744.1;CC chemokine ligand 4;CCL4;CCL4_HUMAN;ccl4l 1;CCL4L1;Chemokine CC Motif Ligand 4;G 26 T lymphocyte secreted protein;G-26 T-lymphocyte-secreted protein;HC21;LAG 1;LAG-1;LAG1;Lymphocyte activation gene 1;Lymphocyte activation gene 1 protein;Macrophage inflammatory protein 1 beta;Macrophage inflammatory protein 1-beta;MGC104418;MGC126025;MGC126026;MIP-1-beta;MIP-1-beta(1-69);MIP-1-beta(3-69);MIP1 beta;MIP1B;MIP1B1;PAT 744;Protein H400;SCYA2;SCYA4;Secreted protein G26;SIS gamma;SIS-gamma;Small inducible cytokine A4;Small-inducible cytokine A4;T cell activation protein 2;T-cell activation protein 2;MIP-1β;Macrophage inflammatory protein-1β
Recombinant Proteins
- Human
- Cynomolgus
- Atlantic Salmon
- Cotton Rat
- Canine
- Mouse
- Rat
- Chicken
- Pig
- Cattle
- Dog
- Rabbit
- E.coli
- Yeast
- CHO
- yeast
- Wheat Germ
- Mammalian Cell
- S.frugiperda
- Human Cell
- HEK293
- HEK293F
- Human Cells
- HEK293T
- GST
- Non
- Fc
- His
- StrepII
- His&GST
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Ccl4 involved in several pathways and played different roles in them. We selected most pathways Ccl4 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CXCR6,PIK3R1,CXCL14,PTK2,GNB4,SRC,KRAS,GM1987,ROCK1,XCL2 |
| Salmonella infection | NOS2B,WASLB,IL6,KLC4,CCL3L3,TLR4BA,RAC1A,MAPK8B,PFN2L,FLNA |
| Cytokine-cytokine receptor interaction | IL6R,CXCL16,PRLR,INHBB,TNFSF10,NGFRB,TNFSF14,TNFSF13B,CCL21,CCL27B |
| NF-kappa B signaling pathway | TRAF1,RELA,NFKBIA,XIAP,IRAK4,PTGS2,PRKCB,ATM,TRIM25,BCL2L1 |
| Toll-like receptor signaling pathway | MAP2K1,MAP2K4A,IFNA7,IFNA8,CD80,NFKBIAB,Ifna15,FOS,TOLLIP,MAPK8A |
| Cytosolic DNA-sensing pathway | IFNA2,IKBKG,Ifna15,NFKBIB,IFNA13,IFNB,IFI202B,POLR3D,NFKBIA,POLR1D |
Protein Function
Ccl4 has several biochemical functions, for example, CCR1 chemokine receptor binding,CCR5 chemokine receptor binding,chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl4 itself. We selected most functions Ccl4 had, and list some proteins which have the same functions with Ccl4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BMP7,CCL20,TARSL2,RAF1,H2AFY,CHRNA5,RTN4RL1,INTS7,SIGLEC5,TCTE3 |
| cytokine activity | BMP7,IL6,Ifnl2,IL17A/F1,GM13289,OSM,Kitl,IFNPHI4,CCL38A.4,LFT2 |
| chemokine activity | CCL25,CCL14,CCL33.3,CXCL32B.1,CXCL9,XCL1,CCL33.2,PF4V1,CCL20B,CXCL12A |
| identical protein binding | GPSM2,NUDT16,AIRE,MDM2,SEPT7,YWHAZ,CNTN2,PLDN,BRI3,LYZ |
| CCR1 chemokine receptor binding | CCL23,CREB3,CCL5,CCL3,CCL7 |
| CCR5 chemokine receptor binding | JAK1,CCL5,CNIH4,CCL3,STAT3 |
Interacting Protein
Ccl4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl4.
SLC30A2;IDE;glgX;rnb
Resources
Research Area
NeuroinflammationInflammatory Mediators
Cytokines and Growth Factors Secreted by VSMC
Regulatory T Cells (Tregs)
CC Chemokines
Related Services
Related Products
References
- Pauta, M; Ribera, J; et al. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. LIVER INTERNATIONAL 35:1383-1392(2015).
- He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).
