CST3
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Official Full Name
cystatin C -
Overview
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013] -
Synonyms
CST3;cystatin C;ARMD11;cystatin-C;cystatin 3;cystatin-3;gamma-trace;post-gamma-globulin;bA218C14.4 (cystatin C);neuroendocrine basic polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- Chicken
- Cattle
- Pig
- Dog
- E.coli
- HEK293
- Human
- Mammalian Cell
- Wheat Germ
- P.pastoris
- Insect Cell
- E. coli
- Human Cell
- Rabbit
- Mammalian cells
- In Vitro Cell Free System
- Human Urine - chronic protein renal tubular proteinuria
- HEK293T
- GST
- His
- Non
- His&GST
- His&Fc&Avi
- His&Myc
- Myc&DDK
Involved Pathway
CST3 involved in several pathways and played different roles in them. We selected most pathways CST3 participated on our site, such as Amyloid formation,Integrated Pancreatic Cancer Pathway,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salivary secretion | PRKG2,CST2,SLC9A1,LYZ2,AMY1A,ATP1A3,CALM2,ITPR3,PRH1,GUCY1B3 |
| Integrated Pancreatic Cancer Pathway | IL11,FST,RB1CC1,NOXA1,CASP12,JUND,GPRC5A,CD82,TFF1,RAPGEF3 |
| Metabolism of proteins | PAPPA,SLC34A2A,TOMM40,ALG10B,NAPG,MBOAT4,SLC30A8,ADAMTS18,TBCA,TOMM70A |
| Amyloid formation | LTF,TGFBI,HIST4H4,HIST2H3C,APCS,TTR,SAA1,RHBDL1,NAT8B,ODAM |
Protein Function
CST3 has several biochemical functions, for example, beta-amyloid binding,cysteine-type endopeptidase inhibitor activity,endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST3 itself. We selected most functions CST3 had, and list some proteins which have the same functions with CST3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | C4A,C3,SERPINA1A,PSMF1,RECK,USP14,STFA2,PZP,C3A.3,SLPI |
| cysteine-type endopeptidase inhibitor activity | Cstb,CST9L,BIRC5A,BIRC5B,FETUB,CARD17,BIRC7,NLRC4,PTTG1,CST8 |
| identical protein binding | KCNH2,SP100,CPT1A,YWHAZ,RUNX1T1,DIAP1,BCL2L1,CD247,MAPK1IP1,TRIM23 |
| protease binding | Cstb,ADAMTSL4,PANX1,TYSND1,MBP,TIMP2A,TTN,FURIN,SERPINB3,PINK1 |
| beta-amyloid binding | GPRASP2,APOEA,HSD17B10,IDE,BACE2,CD74,SORL1,MAPK8IP2,APOEB,TSSK1B |
| protein binding | FBXO25,FBXW11,SHARPIN,GPX3,SDHAF2,TTC39B,DDL-2,SF3B4,BMP10,HDC |
Interacting Protein
CST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST3.
ATXN1;proS;gmhB;ALB
Resources
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References
- Wuttke, M; Schaefer, F; et al. Genome-Wide Association Studies in Nephrology: Using Known Associations for Data Checks. AMERICAN JOURNAL OF KIDNEY DISEASES 65:217-222(2015).
- Lamontagne, M; Timens, W; et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. THORAX 69:997-+(2014).
