C3
-
Official Full Name
complement component 3 -
Overview
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. -
Synonyms
complement C3;Acylation Stimulating Protein Cleavage Product;ASP;C3 and PZP like alpha 2 macroglobulin domain containing protein 1;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1;C3;CO3_HUMAN;Complement C3 precursor;Complement C3c alpha'' chain fragment 2;Complement Component 3;Complement factor 3;CPAMD 1;CPAMD1
Recombinant Proteins
- Human
- Rabbit
- Swine
- C.botulinum
- Cynomolgus
- Clostridium Botulinum
- Rat
- Mouse
- Pig
- Chicken
- Monkey
- Cattle
- Bovine
- E.coli
- HEK293
- Yeast
- C. botulinum
- Clostridium botulinum D bacteriophage
- Human Serum
- Mammalian Cells
- Human serum
- Rabbit Serum
- Cynomolgus Serum
- Mouse Serum
- Rat Serum
- Human Plasma
- Plasma
- His
- Non
- His&GST
- His&T7
- Myc&DDK
- His&Avi
- Flag
- His&SUMO
- His&Fc&Avi
Involved Pathway
C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome,Complement and coagulation cascades,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | CTSL1B,PIK3C3,ATP6V0A1A,TUBB2A,ATP6V0C,DYNC1LI1,H2-AB1,HLA-B,RAB5B,CD209C |
| Systemic lupus erythematosus | HIST1H3H,TROVE2,HIST1H2BA,HIST2H4A,HIST1H2BJ,HIST1H3G,ACTN1,HIST1H2AN,C5,HIST1H2AD |
| Herpes simplex infection | DDX58,IFNAR2,H2-Q10,IRF3,CD74A,SRSF1A,SRSF6B,TAP2,NFKBIA,CUL1B |
| Pertussis | CASP1,C1R,ITGB2L,CXCL5,CALML3,MAPK8,C5,IL6,C1QB,IRF3 |
| Complement and coagulation cascades | SERPINF2,C6,MASP2,THBD,F3,C2,F5,C4BPB,Hc,SERPINA5 |
| Tuberculosis | PPP3R2,TGFB3,MAPK10,HSPA9,CALML5,TLR1,NOS2,ITGB2L,FCGR4,FADD |
| Viral carcinogenesis | ACTN1,NFKB1,REL,ATF4,HDAC2,HIST1H4G,CREB3L1,HDAC10,EP300,GTF2A1 |
| Staphylococcus aureus infection | C4A,FCGR3B,CFI,CFH,SELPLG,HLA-DQA2,C1QB,MBL1,FCGR2A,C2 |
| Legionellosis | RAB1,EEF1G,EEF1A1,TLR5,HSPA1A,TLR2,NFKBIA,NLRC4,VCP,IL6 |
Protein Function
C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding,cofactor binding,endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TAGLN,CLSTN2,RAP1GAP,RABGAP1L,MCM5,MRPL1,DSG1A,ACSF2,ZBTB16,RFFL |
| cofactor binding | WWOX,ASNS,DDO,PAH,TKT,ACLYA,HIF1AN,TYMS,ME3,PHYH |
| receptor binding | ECI2,CCL13,HMGCL,ABL1,TAC4,IL28A,FGF8A,Ren1,TENM2,DHRS4 |
| lipid binding | PFN3,DLC1,APODA.2,RBP2A,SH3GL2,CRABP2B,CLINT1,LIPF,BAIAP2L2B,DBIL5 |
| endopeptidase inhibitor activity | C3A.2,CST3,RECK,WFDC2,C3A.6,A1i3,AHSG,MUG2,CST7,C4A |
Interacting Protein
C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.
VSIG4;VSIG4;CD46;d3jib2_staau;IGM;VHL;ASF1B;TGM2;q99ib8-pro_0000045598;q99ib8-pro_0000045601;d-mannose;crlkekhc;IGHM
Resources
Research Area
Serine Proteases and RegulatorsAdipocytokines
Alternative Complement Pathway
Classical Complement Pathway
Related Services
Related Products
References
- Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
- Yue, PJ; He, L; et al. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. REGULATORY TOXICOLOGY AND PHARMACOLOGY 71:285-294(2015).
