ASPA
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Official Full Name
aspartoacylase -
Overview
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate.;NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein;is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript;variants have been found for this gene. -
Synonyms
ASPA;aspartoacylase;aspartoacylase (aminoacylase 2, Canavan disease);ACY2;aminoacylase 2;ASP;Canavan disease;ACY 2;ACY-2;ACY2_HUMAN;Aminoacylase-2;Aminoacylase2;Aspartoacylase (Canavan disease);NUR 7;NUR7;OTTMUSP00000006437;RP23-213I10.1;Small lethargic;OTTHUMP00000115814
Recombinant Proteins
- Bacillus subtilis
- Human
- Cynomolgus
- Rhesus macaque
- Zebrafish
- Rat
- Mouse
- E. coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- Insect Cell
- Yeast
- E.coli
- His
- Myc&DDK
- GST
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
ASPA involved in several pathways and played different roles in them. We selected most pathways ASPA participated on our site, such as Alanine, aspartate and glutamate metabolism,Histidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ACO2,MDH1,ATP5G3A,ACSL4,PON2,UAP1,POLR1C,AMDHD1,MIBP,GCDHB |
| Histidine metabolism | MAOA,HNMT,ALDH9A1A.1,HAL,ALDH3B1,ALDH9A1,ALDH7A1,AMDHD1,MAOB,ALDH9A1B |
| Alanine, aspartate and glutamate metabolism | ASL,ADSL,GFPT2,ASS1,GLS,GLSA,PPAT,GPT,AGXTA,AGXTB |
Protein Function
ASPA has several biochemical functions, for example, aminoacylase activity,aspartoacylase activity,hydrolase activity, acting on ester bonds. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPA itself. We selected most functions ASPA had, and list some proteins which have the same functions with ASPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MTDH,HACE1,DNAJB2,NEDD4,CD200R4,MYO1E,RNF5,S100B,APOA2,KIF23 |
| hydrolase activity, acting on ester bonds | LIPM,APMAP,ENDOU2,LIPN,PTER,C11orf54,ACY3.1,CES1C,SMFN,PGAP3 |
| metal ion binding | ZDHHC23B,LRP2,Atp8a2,PRKCE,ZNF202,MOCS1,SMG1,ZNF497,SP6,KDM1B |
| aminoacylase activity | ACY1,DARS,CAT,ACY3 |
Interacting Protein
ASPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPA here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPA.
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References
- Chang, Z; Lu, M; et al. Production of disulfide bond-rich peptides by fusion expression using small transmembrane proteins of Escherichia coli. AMINO ACIDS 47:579-587(2015).
- Abad, FX; Busquets, N; et al. Serological and virological surveys of the influenza A viruses in Antarctic and sub-Antarctic penguins. ANTARCTIC SCIENCE 25:339-344(2013).
