ACVR2A
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Official Full Name
activin receptor IIA -
Overview
Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. -
Synonyms
ACTRII;ACVR2;activin receptor IIA;ACVR2A
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Bovine
- Mus musculus
- Xenopus laevis
- Insect Cell
- HEK293
- Human Cell
- Sf21 Insect Cell
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- Mammalian cells
- E. coli
- In Vitro Cell Free System
- CHO
- E.coli
- HEK293T
- E.coli expression system
- E. coli expression system
- GST
- His
- Fc
- C-His&hFc
- Non
- His&Fc
- mFc
- His & Fc & Avi
- His&GST
- Flag
Involved Pathway
ACVR2A involved in several pathways and played different roles in them. We selected most pathways ACVR2A participated on our site, such as Cytokine-cytokine receptor interaction,TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | WNT7B,FZD3,ISL1,AXIN2,FZD1,IL6ST,LHX5,PIK3R1,WNT8A,SKIL |
| Cytokine-cytokine receptor interaction | GDF5,BMP7A,IFNA14,TNFSF18,ACVR2B,PDGFRA,Il23a,CXCL1,CXCL6,VEGFC |
| TGF-beta signaling pathway | GDF6,TGFB1A,GDF6A,CHRD,BMPR2A,THBS1,AMH,ZFYVE9,MYCB,BMPR2B |
Protein Function
ACVR2A has several biochemical functions, for example, ATP binding,PDZ domain binding,contributes_to activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2A itself. We selected most functions ACVR2A had, and list some proteins which have the same functions with ACVR2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | CSNK1G2B,MAPK6,PAK7,SRPK2,SRPK1,RPS6KA3,MAPK8B,SMOK2B,NEK10,PRKCI |
| growth factor binding | ACVR1C,TEK,GHR,BMPR2,IGFBP2B,LTBP2,FLT4,HTRA1B,REG3B,IL6ST |
| receptor signaling protein serine/threonine kinase activity | BMPR1BB,PAK2A,ACVR1,AMHR2,PANK1A,TGFBR2,ACVR2AA,BMPR2A,ACVRL1,SLKA |
| transmembrane receptor protein serine/threonine kinase activity | ACVR1L,ACVRL1,TGFBR2,ACVR1B,BMPR1BB,BMPR2A,ACVR2AA,BMPR1AA,BMPR1A,ACVR1BA |
| contributes_to activin-activated receptor activity | ACVR1B |
| metal ion binding | GDPD3,ZNF45L,MAP3K3,ZEB2B,NRP2,ASNA1,DNAJA2,ZNF843,NDUFV2,CYGB1 |
| protein binding | ZBED1,DYNC1H1,PRDX1,RPS28,LRFN2,ZBP1,CTNNBL1,CD209,MPZL2,NAT9 |
| ATP binding | PKM2,FGFR4,BMPR2B,DDX11,FGFR2,HSPA12B,TP53RK,ABCD3A,NARS,MAPK3 |
| PDZ domain binding | SNTA1,Apba1,PLEKHA1,SRR,LNX2,PARK2,ATP2B3B,SLC22A12,MAP2K2,PDZK1 |
Interacting Protein
ACVR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2A.
Magi2;DAXX;linkable pd173955 analogue
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