Recombinant Human ACVR2A, His-tagged
Cat.No. : | ACVR2A-6994H |
Product Overview : | Recombinant human ACVR2A (161-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | His |
Protein Length : | 161 aa-end |
Description : | ACVR2A encodes activin A type II receptor that are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins is an autocrine/paracrine regulator in the human placenta. ACVR2A is highly expressed in human brain and ovary. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~47 kDa |
Purity : | >90% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | ACVR2A activin A receptor, type IIA [ Homo sapiens ] |
Official Symbol | ACVR2A |
Synonyms | ACVR2A; activin A receptor, type IIA; activin A receptor, type II , ACVR2; activin receptor type-2A; ACTRII; ACVR2; |
Gene ID | 92 |
mRNA Refseq | NM_001616 |
Protein Refseq | NP_001607 |
MIM | 102581 |
UniProt ID | P27037 |
Chromosome Location | 2q22.2-q23.3 |
Pathway | ALK1 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Developmental Biology, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; |
Function | ATP binding; contributes_to activin binding; activin receptor activity, type II; contributes_to activin-activated receptor activity; coreceptor activity; growth factor binding; inhibin beta-A binding; inhibin beta-B binding; metal ion binding; nucleotide binding; protein binding; contributes_to protein binding; protein self-association; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; |
◆ Recombinant Proteins | ||
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ACVR2A-2889H | Active Recombinant Human ACVR2A protein, Fc-tagged | +Inquiry |
ACVR2A-01H | Recombinant Active Human ACVR2A Protein, His-tagged | +Inquiry |
RFL-4199MF | Recombinant Full Length Mouse Activin Receptor Type-2A (Acvr2A) Protein, His-Tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
ACVR2A-3096HCL | Recombinant Human ACVR2A cell lysate | +Inquiry |
ACVR2A-2280MCL | Recombinant Mouse ACVR2A cell lysate | +Inquiry |
Not For Human Consumption!
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