Recombinant Human ACVR2A Protein, GST-tag

• Cat.No.: ACVR2A-510H
• Product Overview: This recombinant fusion protein consists of full-length activin A receptor kinase and a glutathione S-transferase (GST) tag was expressed in Baculovirus. It is validated in the LanthaScreen® Eu Kinase Binding Assay. No special measures were taken to activate this kinase.
  • Compatible and validated with the LanthaScreen® Eu Kinase Binding Assay
  • Expressed in insect cells
  • GST tagged for use with Eu-labeled GST antibody

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-513aa
• Description: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
• Form: Frozen
• Molecular Mass: 85.3 kDa
• Storage: Store at -80 centigrade. At first use, aliquot and store at -80 centigrade to avoid multiple freeze-thaws.
• Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% NP-40, 2 mM DTT and 50% glycerol.
• Shipping: Dry Ice

Gene Information

• Gene Name: ACVR2A activin A receptor type 2A [ Homo sapiens (human) ]
• Official Symbol: ACVR2A
• Synonyms: ACVR2A; activin A receptor type 2A; ACVR2; ACTRII; activin receptor type-2A; activin A receptor, type IIA; EC 2.7.11.30
• Gene ID: 92
• mRNA Refseq: NM_001616
• Protein Refseq: NP_001607
• MIM: 102581
• UniProt ID: P27037