IL5RA
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Official Full Name
interleukin 5 receptor, alpha -
Overview
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.<br/>The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. -
Synonyms
IL5RA;interleukin 5 receptor, alpha;IL5R;interleukin-5 receptor subunit alpha;CD125;CDw125;CD125 antigen;IL-5R subunit alpha;IL-5 receptor subunit alpha;interleukin 5 receptor type 3;interleukin-5 receptor alpha chain;HSIL5R3;MGC26560
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Mus musculus
- HEK293
- Mammalian cells
- Sf21 Insect Cell
- Insect Cells
- Mammalian Cell
- E.coli
- Insect Cell
- Human Cell
- HEK293T
- CHO
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Fc
- Non
- His&T7
- Myc&DDK
- His&Avi
- His&Fc&Avi
Involved Pathway
IL5RA involved in several pathways and played different roles in them. We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL5RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMP7A,KITLG,TNFRSF10A,TNFSF11,CCL4,CSF1R,TGFBR1A,TNFRSF4,Flt3l,LEPR |
| Jak-STAT signaling pathway | SOCS4,PIK3R3B,IL15RA,SOCS1A,PRLR,IL21R.1,IL11RA,PTPN2B,CSF3R,IFNA14 |
| Hematopoietic cell lineage | CD1A,MME,CD1E,HLA-DRB5,CD3E; CD3D,CD8A,Il6ra, B2M,FLT3LG,CD4 |
Protein Function
IL5RA has several biochemical functions, for example, interleukin-5 receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL5RA itself. We selected most functions IL5RA had, and list some proteins which have the same functions with IL5RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ATPAF2,CCDC135,HSPA4,ARHGAP5,INTS5,LRRC4C,OCLN,DUSP9,PDIA4,PXMP4 |
Interacting Protein
IL5RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL5RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL5RA.
IL5;CSF2RB;GRB2
Resources
Research Area
Negative Regulators of the Jak/STAT PathwayReceptors in the Jak/STAT Pathway
Basophils
Eosinophils
T Cell Cytokine Signaling
CD Antigen (Helper T Cells)
Other Interleukins & Receptors
T Follicular Helper (Tfh) Cells
Related Services
Related Products
References
- Losol, P; Kim, SH; et al. A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).
