Recombinant Rat TOP1 Protein

• Cat.No.: TOP1-6223R
• Product Overview: Recombinant Rat TOP1 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Rat
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Top1 topoisomerase (DNA) I [ Rattus norvegicus ]
• Official Symbol: TOP1
• Gene ID: 64550
• mRNA Refseq: NM_022615.1
• Protein Refseq: NP_072137.1
• UniProt ID: Q9WUL0

Reviews

10/17/2019

Accurate protein structural analysis; a key for structural biology.

10/06/2018

High-quality protein crystallography; essential for structural biology.

05/30/2018

Timely protein characterization; vital for our research projects.

Q&As

What is the role of TOP1 in the repair of DNA damage caused by environmental factors and chemotherapeutic agents?

TOP1 repairs DNA damage, maintaining genomic stability under stress.

How do post-translational modifications of TOP1, such as phosphorylation, affect its enzymatic activity and interaction with DNA?

Post-translational modifications like phosphorylation affect TOP1's activity and DNA interaction.

How do mutations in the TOP1 gene contribute to genomic instability and the development of certain cancers?

Mutations in TOP1 cause genomic instability, increasing cancer risk.

What are the effects of TOP1 inhibitors on cancer cell proliferation and survival?

TOP1 inhibitors lead to cancer cell death and inhibit tumor growth by disrupting DNA processes.

How does TOP1 interact with other proteins in the DNA repair and replication machinery?

TOP1 works with other DNA repair proteins, ensuring accurate DNA synthesis.

How does TOP1 regulate DNA unwinding and re-ligation during transcription and replication?

TOP1 regulates DNA unwinding by creating transient breaks, aiding transcription and replication.

What are the implications of TOP1 expression levels in predicting the response to chemotherapy in cancer patients?

TOP1 expression levels predict chemotherapy responses in cancer treatment.