Recombinant Rat Fxr1 Protein, His&GST-tagged

• Cat.No.: Fxr1-1538R
• Product Overview: Recombinant Rat Fxr1 Protein (Leu375-Asp568) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Predicted to enable RNA binding activity; protein dimerization activity; and translation regulator activity. Predicted to be involved in several processes, including positive regulation of response to DNA damage stimulus; regulation of filopodium assembly; and regulation of gene expression. Predicted to be located in several cellular components, including costamere; glutamatergic synapse; and perinuclear region of cytoplasm. Predicted to be part of polysome. Predicted to be active in several cellular components, including dendrite; growth cone; and postsynaptic density. Orthologous to human FXR1 (FMR1 autosomal homolog 1).
• Source: E. coli
• Species: Rat
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 51.3 kDa
  Accurate Molecular Mass: 55 kDa
• Protein length: Leu375-Asp568
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Fxr1 fragile X mental retardation gene 1, autosomal homolog [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Fxr1
• Synonyms: FXR1; fragile X mental retardation gene 1, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; Fxr1h
• Gene ID: 361927
• mRNA Refseq: NM_001012179
• Protein Refseq: NP_001012179
• UniProt ID: Q5XI81

Reviews

06/08/2023

Highly recommended service, valuable for research projects.

02/08/2022

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02/18/2021

Dependable results, a key to research success.

Q&As

What potential therapeutic applications arise from targeting FXR1 in muscular disorders?

Targeting FXR1 could offer therapeutic strategies for treating muscle disorders linked to RNA metabolism abnormalities.

What is the primary role of FXR1 in RNA metabolism?

FXR1, an RNA-binding protein, is involved in regulating RNA metabolism, particularly mRNA processing and turnover.

How does FXR1 interact with other RNA-binding proteins?

FXR1 interacts with a network of RNA-binding proteins, coordinating the regulation of mRNA metabolism.

What role does FXR1 play in protein synthesis?

FXR1 plays a crucial role in modulating protein synthesis by influencing mRNA availability and translation.

How does FXR1 contribute to mRNA stability?

It contributes to mRNA stability, affecting the lifespan and translation efficiency of mRNAs.

What is the impact of altered FXR1 activity on muscle development?

Altered FXR1 activity can affect muscle development and function, potentially leading to muscle-related disorders.

How do genetic variations in FXR1 affect cellular processes?

Genetic mutations in FXR1 can disrupt normal RNA processing and protein synthesis, impacting various cellular functions.