Recombinant Full Length Human FXR1 Protein, GST-tagged

• Cat.No.: FXR1-587HF
• Product Overview: Recombinant full length Human FXR1(1 a.a. - 621 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. Theseproteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 96.1 kDa
• Protein length: 621 amino acids
• AA Sequence: MAELTVEVRG SNGAFYKGFI KDVHEDPLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE EKINTLKEEN TQEAAVLNGV S
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: FXR1 fragile X mental retardation, autosomal homolog 1 [ Homo sapiens ]
• Official Symbol: FXR1
• Synonyms: FXR1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation syndrome-related protein 1; hFXR1p; FXR1P
• Gene ID: 8087
• mRNA Refseq: NM_001013438
• Protein Refseq: NP_001013456
• MIM: 600819
• UniProt ID: P51114

Reviews

06/08/2023

Highly recommended service, valuable for research projects.

02/08/2022

Exceptional expertise, elevates our research standards.

02/18/2021

Dependable results, a key to research success.

Q&As

What potential therapeutic applications arise from targeting FXR1 in muscular disorders?

Targeting FXR1 could offer therapeutic strategies for treating muscle disorders linked to RNA metabolism abnormalities.

What is the primary role of FXR1 in RNA metabolism?

FXR1, an RNA-binding protein, is involved in regulating RNA metabolism, particularly mRNA processing and turnover.

How does FXR1 interact with other RNA-binding proteins?

FXR1 interacts with a network of RNA-binding proteins, coordinating the regulation of mRNA metabolism.

What role does FXR1 play in protein synthesis?

FXR1 plays a crucial role in modulating protein synthesis by influencing mRNA availability and translation.

How does FXR1 contribute to mRNA stability?

It contributes to mRNA stability, affecting the lifespan and translation efficiency of mRNAs.

What is the impact of altered FXR1 activity on muscle development?

Altered FXR1 activity can affect muscle development and function, potentially leading to muscle-related disorders.

How do genetic variations in FXR1 affect cellular processes?

Genetic mutations in FXR1 can disrupt normal RNA processing and protein synthesis, impacting various cellular functions.