Recombinant Murine Icos Ligand, Fc Chimera

• Cat.No.: Icosl-2166M
• Product Overview: Recombinant Murine Icos Ligand is produced in mammalian cells andfused with fused with human IgG1Fc. B7H2 extracellular domain (C-terminus fused with human IgG1 Fc) contains 457amino acids with predicted MW 51.21D x 2 (dimmer), and 12 cysteines (Fc has 6). It also has 6 N-link glycosylation sites with MW increase up to 30 kDa. It is ligand for the T-cell specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and differentiation. It induces also B-cell proliferation and differentiation in plasma cells.

Specification

• Cat. No.: Icosl-2166M
• Description: Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein.
• Source: Mammalian cells.
• Purity: >90%.
• Quantity: 2.0mg/2ml PBS.
• Storage: -70°C

Gene Information

• Gene Name: Icosl icos ligand [ Mus musculus ]
• Synonyms: Icosl; icos ligand; B7-H2; B7h; B7RP-1; GL50; GL50-B; ICOS-L; LICOS
• Gene ID: 50723
• mRNA Refseq: NM_015790
• Protein Refseq: NP_056605
• UniProt ID: Q9JHJ8
• Chromosome Location: 10 C1
• Pathway: Cell adhesion molecules (CAMs)
• Function: protein binding; receptor activity