Icosl
-
Official Full Name
icos ligand -
Overview
ICOS ligand is a protein that in humans is encoded by the ICOSLG gene. ICOSLG has also been designated as CD275. -
Synonyms
ICOSL;icos ligand;B7 H2;B7 homolog 2;B7 like protein Gl50;B7 related protein 1;B7-H2;B7-like protein Gl50;B7-related protein 1;B7H2;B7RP 1;B7RP-1;B7RP1;CD 275;CD275;CD275 antigen;GL 50;GL50;ICOS LG;ICOSL_HUMAN;ICOSLG;Inducible T cell co stimulator ligand;KIAA0653;LICOS;Transmembrane protein B7 H2 ICOS ligand;B7h;GI50;GL50-B;ICOS-L;Ly115l;AU044799;BG071784;mKIAA0653
Recombinant Proteins
- Mouse
- HEK293
- CHO
- Mammalian Cell
- E.coli
- HEK293T
- Mammalian cells
- His
- His&Fc
- Fc
- C-His&hFc
- His&T7
- Myc&DDK
Involved Pathway
Icosl involved in several pathways and played different roles in them. We selected most pathways Icosl participated on our site, such as Cell adhesion molecules (CAMs),Intestinal i,ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with Icosl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CNTN1A,CLDN15LB,NRXN1,NLGN2A,NCAM1,NEO1,ITGAV,MAG,F11R.1,NLGN3 |
| Intestinal i | IL6,LTBR,HLA-DPA1,IL-15RA,TNFRSF13B,Il2,MHC2A,CD80,BLA,IL15RA |
| ne network for IgA production | CD80,HLA-DRB1,BLB1,IL15,PIGR,MAP3K14,HLA-DQA2,AICDA,CCR9A,CXCL12 |
Protein Function
Icosl has several biochemical functions, for example, protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Icosl itself. We selected most functions Icosl had, and list some proteins which have the same functions with Icosl. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ANKHD1,AKR1A1,WDR20,ACVR1B,EPN2,SALL1,TUBGCP3,PRKCI,DPM3,CRCT1 |
| receptor binding | FGF8A,SERPINE1,HAO1,MTSS1,IZUMO1,F7,A2M,ALCAM,ACOX2,CADM2A |
Interacting Protein
Icosl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Icosl here. Most of them are supplied by our site. Hope this information will be useful for your research of Icosl.
Resources
Research Area
Cancer Drug TargetsEpithelial Cell Markers and Intracellular Molecules
B7/CD28 Family
Co-stimulatory Molecules
Thymus-Dependent B Cell Activation
T Follicular Helper (Tfh) Cells
Immune Checkpoints
Related Services
Related Products
References
- Nazzal, D; Gradolatto, A; et al. Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand. CELL DEATH & DISEASE 5:-(2014).
- Marczynska, J; Ozga, A; et al. The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses. JOURNAL OF IMMUNOLOGY 193:2753-2763(2014).
