Recombinant Murine Collagen, Type XVIII, Alpha 1, Fc Chimera

Cat. No. :	Col18a1-200M
Description :	Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin familyEndostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
Source :	Pichia pastoris.
Biochem/Physiol Actions :	Endostatin is a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo; specifcally inhibits endothelial cell proliferation.
Physical Form :	17 mM citric-phosphate buffer, pH 6.2.
Assay :	≥95% (HPLC).
Concentration :	4 mg/mL (17 mM citric-phosphate buffer, pH 6.2).
Total Impurities :	Endotoxin, tested.
Storage Temp :	−70°C.

Gene Name	Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ]
Synonyms	Col18a1; collagen, type XVIII, alpha 1; endostatin
Gene ID	12822
mRNA Refseq	NM_001109991
Protein Refseq	NP_001103461
UniProt ID	P39061
Chromosome Location	10 B5-C1; 10 41.3 cM
Function	binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity