Recombinant Mouse Wwc1 Protein, Myc/DDK-tagged

• Cat.No.: Wwc1-7013M
• Product Overview: Purified recombinant protein of Mouse WW, C2 and coiled-coil domain containing 1 (cDNA clone MGC:47054 IMAGE:5116674), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance. Regulates collagen-stimulated activation of the ERK/MAPK cascade.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 74.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wwc1 WW, C2 and coiled-coil domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Wwc1
• Synonyms: Wwc1; WW, C2 and coiled-coil domain containing 1; Ki; Kibra; AA408228; AU017197; BC037006; protein KIBRA; WW domain-containing protein 1; kidney and brain protein; protein WWC1
• Gene ID: 211652
• mRNA Refseq: NM_170779
• Protein Refseq: NP_740749
• UniProt ID: Q5SXA9