WWC1
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Official Full Name
WW and C2 domain containing 1 -
Overview
The Hippo pathway is an important evolutionarily conserved signaling pathway that controls organ size and tumor suppression by inhibiting cell proliferation and promoting apoptosis. An integral function of the Hippo pathway is to repress the activity of Y -
Synonyms
WWC1;WW and C2 domain containing 1;WW, C2 and coiled coil domain containing 1;protein KIBRA;KIAA0869;KIBRA;protein WWC1;HBeAg-binding protein 3;kidney and brain protein;WW, C2 and coiled-coil domain containing 1;HBEBP3;HBEBP36;FLJ10865;FLJ233
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&GST
- His&Fc&Avi
Involved Pathway
WWC1 involved in several pathways and played different roles in them. We selected most pathways WWC1 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | PPP2R2D,GSK3B,FRMD6,BMPR1A,PPP1CC,BMP2,ITGB2,SMAD7,CCND1,CTNNA3 |
Protein Function
WWC1 has several biochemical functions, for example, kinase binding,protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by WWC1 itself. We selected most functions WWC1 had, and list some proteins which have the same functions with WWC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TAF11,STIL,ESRRB,CARM1,CRSP7,NR1I2,HTATIP2,WWTR1,SUB1A,YAP1 |
| protein binding, bridging | FLRT1,GOLGA5,FSCN3,CSTA,NEFL,NUFIP1,FRMD4A,PSMC6,RAD50,NCK1 |
| protein complex scaffold | DLG1,AKAP6,MAP2K2,MAGI3,DISC1,SEPT2,AXIN1,ARRB2,CHCHD3,MPP7 |
| kinase binding | CDC37,PPP2R5A,PARK7,CTNNB1,TAX1BP1,UBQLN1,STX1A,TNFAIP3,HAP1,RB1 |
| protein binding | PAGE5,MEIS1,COPS6,Trl,CNOT4,MAB21L1,Anks6,SET,SRGN,ACTL8 |
Interacting Protein
WWC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWC1.
AMOT;YWHAZ;AIFM1;p29991-pro_0000037940;p29991-pro_0000037943;MAPK6;q2i360_hbv;RIF1;CDC73;FAM219A;TNIK;EPB41L2;YWHAQ;YWHAB;YWHAG;YWHAE;DYNLL1;YWHAH;PTPN14
WWC1 Related Signal Pathway
Resources
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References
- Zhi, X; Chen, CS; et al. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. CELLULAR AND MOLECULAR LIFE SCIENCES 69:1425-1434(2012).
- Matsumoto, H; Takahama, M; et al. Suppression of WWP1 Gene Via RNAi Induced the Reduction of Proliferation Rate of C2C12 Myoblasts. JOURNAL OF POULTRY SCIENCE 47:288-293(2010).
