Recombinant Mouse Unc5c Protein, Myc/DDK-tagged

• Cat.No.: Unc5c-6839M
• Product Overview: Purified recombinant protein of mouse full-length unc-5 netrin receptor C (Unc5c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
• Molecular Mass: 103.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Unc5c unc-5 netrin receptor C [ Mus musculus (house mouse) ]
• Official Symbol: Unc5c
• Synonyms: UNC5C; unc-5 homolog C (C. elegans); netrin receptor UNC5C; unc5 homolog 3; UNC-5 homolog 3; protein unc-5 homolog 3; protein unc-5 homolog C; rostral cerebellar malformation protein; rcm; Unc5h3; AI047720; 6030473H24; B130051O18Rik
• Gene ID: 22253
• mRNA Refseq: NM_009472
• Protein Refseq: NP_033498
• UniProt ID: O08747