Recombinant Mouse Twist2 Protein, Myc/DDK-tagged

• Cat.No.: Twist2-6741M
• Product Overview: Purified recombinant protein of mouse full-length twist basic helix-loop-helix transcription factor 2 (Twist2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
• Molecular Mass: 18.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Twist2 twist basic helix-loop-helix transcription factor 2 [ Mus musculus (house mouse) ]
• Official Symbol: Twist2
• Synonyms: TWIST2; twist homolog 2 (Drosophila); twist-related protein 2; dermo-1; dermis expressed 1; dermis-expressed protein 1; Dermo1; bHLHa39
• Gene ID: 13345
• mRNA Refseq: NM_007855
• Protein Refseq: NP_031881
• UniProt ID: Q9D030