TWIST2
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Official Full Name
twist family bHLH transcription factor 2 -
Overview
The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014] -
Synonyms
TWIST2;twist family bHLH transcription factor 2;FFDD3;DERMO1;SETLSS;bHLHa39;twist-related protein 2;twist homolog 2;dermis-expressed protein 1;twist-related bHLH protein Dermo1;class A basic helix-loop-helix protein 39;twist basic helix-loop-helix transcription factor 2
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- Human
- Mouse
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TWIST2 involved in several pathways and played different roles in them. We selected most pathways TWIST2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TWIST2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | RAC1,PDPK1,HIF1A,RPS6KB1,PDCD4,IGF2,PTCH1,MAP2K1,AKT2,CAV2 |
Protein Function
TWIST2 has several biochemical functions, for example, DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TWIST2 itself. We selected most functions TWIST2 had, and list some proteins which have the same functions with TWIST2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | HPS1,SRFA,AHRRA,ERBB2,NCOA2,AHRR,DAO1,NEUROD6A,TAL2,NEUROD4 |
| DNA binding | TOX4,DLX2B,JUNBB,HOXA13,HIST1H111R,IRX5,NR1D1,NKX3.2,CLOCK,DMBX1 |
| protein binding | HIST1H2AH,VASNA,SOCS7,UBE2F,ATP6V0D2,GRB2,DPYD,RPL9,C17orf28,BTN3A1 |
| transcription factor activity, RNA polymerase II transcription factor binding | NACC2,GATA4,YAP1,MYOCD,ATF4,SRF,MAMSTR,GTF2E1,THRAA,LHX2 |
| chromatin binding | AAAS,TICRR,KLF14,CBX4,SAFB,MTA3,HMGXB4A,PATZ1,URI1,ZGLP1 |
| transcription factor activity, sequence-specific DNA binding | GABPA,ZFP367,ZNF643,NR1D2B,PRDM15,JUNBA,FOXB1A,ZFP639,NR6A1A,ZFP821 |
| protein domain specific binding | PRKCZ,STXBP1,TRP63,NF2,CA,FOXA1,ITGA3,ARL1,VAPA,EHD2 |
Interacting Protein
TWIST2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TWIST2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TWIST2.
CCM2;TCF4;TCF12;ETS2;TP53;PLCG2;CRK
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