Recombinant Mouse Tulp3 Protein, Myc/DDK-tagged

• Cat.No.: Tulp3-6737M
• Product Overview: Purified recombinant protein of mouse full-length tubby-like protein 3 (Tulp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 51.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tulp3 tubby-like protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Tulp3
• Synonyms: TULP3; tub; tubby-related protein 3; AI316887; 2310022L06Rik
• Gene ID: 22158
• mRNA Refseq: NM_011657
• Protein Refseq: NP_035787
• UniProt ID: O88413