TULP3

  • Official Full Name

    tub

  • Overview

    This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.

  • Synonyms

    TULP3;tub;tubby-related protein 3;TUBL3;MGC45295;Tubby like protein 3;Tubby related protein 3;Tubby-like protein 3;TUBL 3;TULP 3;TULP3_HUMAN

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • DDK
  • Myc
  • Non
  • GST
  • Avi
  • Fc
  • Flag

    Involved Pathway

    TULP3 involved in several pathways and played different roles in them. We selected most pathways TULP3 participated on our site, such as Hedgehog off state,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with TULP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog off state GPR161,MKS1,WDR35,TTC21B,IFT172,IFT52,RPGRIP1L,IFT88,INTU,WDR19
    Signal Transduction GPR65,RGS10,CDC42EP3,UTS2,VIP2,NPS,SDR16C5,ZNRF3,INSL5,RSPO1
    Signaling by Hedgehog DZIP1,DISP2,KIF7,BOC,SCUBE2,WDR35,IFT122,IFT172,NOTUM1A,CDON

    Protein Function

    TULP3 has several biochemical functions, for example, enzyme binding,phosphatidylinositol binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TULP3 itself. We selected most functions TULP3 had, and list some proteins which have the same functions with TULP3. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol-4,5-bisphosphate binding SLC9A1,Apba1,AMER2,EXOC1,FAM21C,STXBP6,PHLDA3,FCHO2,TIRAP,D6WSU116E
    protein complex binding TRADD,CDK5RAP1,NFYB,NCKAP1,Apba1,CDK5RAP2,HSPD1,DRD1,BRK1,SH2B3
    protein binding RNH1,RAB21,CCDC43,MOBP,WFIKKN1,PRMT2,SLC30A2,TDRKH,OSTB,CSN3
    enzyme binding Slc4a2,C2orf56,HIF1A,PPP1R3B,PEX7,JUND,DDX5,SCNM1-PS,MDM4,UGT1A3
    phosphatidylinositol binding TULP4,SNX9,PIK3C2B,HIP1RB,SNX22,SNX1B,ITPR1,SNX27A,SNX29,FES

    Interacting Protein

    TULP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TULP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TULP3.

    PSTPIP1;MAGEA6;KRTAP10-5;KRTAP10-7;ANKRD54;ROPN1

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