Recombinant Mouse Tra2b Protein, Myc/DDK-tagged

• Cat.No.: Tra2b-5815M
• Product Overview: Purified recombinant protein of mouse full-length splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (cDNA clone MGC:102169 IMAGE:6828358),, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 26.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tra2b transformer 2 beta [ Mus musculus (house mouse) ]
• Official Symbol: Tra2b
• Synonyms: Tra2b; transformer 2 beta; Sfr; Sil; SIG-41; Sfrs10; Silg41; TRA2beta; D16Ertd266e; 5730405G21Rik; transformer-2 protein homolog beta; silica-induced gene 41 protein; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); transformer 2 beta homolog; transformer-2 protein homolog B
• Gene ID: 20462
• mRNA Refseq: NM_009186
• Protein Refseq: NP_033212
• UniProt ID: P62996