Recombinant Mouse Suz12 Protein, Myc/DDK-tagged

• Cat.No.: Suz12-6234M
• Product Overview: Purified recombinant protein of mouse full-length SUZ12 polycomb repressive complex 2 subunit (Suz12), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 83.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Suz12 SUZ12 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]
• Official Symbol: Suz12
• Synonyms: SUZ12; suppressor of zeste 12 homolog (Drosophila); polycomb protein Suz12; suppressor of zeste 12 protein homolog; AI195385; AU016842; AW536442; mKIAA0160; D11Ertd530e; RP23-253E9.4; 2610028O16Rik; KIAA0160
• Gene ID: 52615
• mRNA Refseq: NM_199196
• Protein Refseq: NP_954666
• UniProt ID: Q80U70