SUZ12
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Official Full Name
SUZ12 polycomb repressive complex 2 subunit -
Overview
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009] -
Synonyms
SUZ12;SUZ12 polycomb repressive complex 2 subunit;CHET9;JJAZ1;polycomb protein SUZ12;chET 9 protein;joined to JAZF1 protein;suppressor of zeste 12 homolog;suppressor of zeste 12 protein homolog;chromatin precipitated E2F target 9 protein
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- HEK293
- E.coli
- Mammalian Cells
- Non
- Avi
- Fc
- His
- DDK
- Myc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SUZ12-31487TH | Recombinant Human SUZ12 | Wheat Germ | Human | Non | 100 amino acids |
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| SUZ12-1330HCL | Recombinant Human SUZ12 293 Cell Lysate | HEK293 | Human | Non |
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| SUZ12-2141H | Recombinant Human SUZ12 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| SUZ12-2141H-B | Recombinant Human SUZ12 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SUZ12-2744H | Recombinant Human SUZ12 Protein, His-tagged | E.coli | Human | His | Leu448-Phe639 |
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| SUZ12-35H | Recombinant Human SUZ12 Protein, Myc/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Suz12-6234M | Recombinant Mouse Suz12 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| SUZ12-763HFL | Recombinant Full Length Human SUZ12 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
SUZ12 involved in several pathways and played different roles in them. We selected most pathways SUZ12 participated on our site, such as Cellular Senescence,Cellular responses to stress,Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUZ12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PKMTs methylate histone lysines | SUZ12A,SUZ12B,SETD3,SMYD3,ATF7IP,DPY30,EHMT2,RBBP5,SMYD2,SMYD2A |
| Gene Expression | ZNF350,ZNF79,PLD6,FARS2,SF3B2,TET3,RPP38,POP7,ADARB1A,COX6A1 |
| Cellular Senescence | E2F3,POT1A,HIST1H1B,HTATIP,KDM6B,HIST1H1D,TNIK,EED,PHC1,PHC2 |
| Chromatin modifying enzymes | NCOA2,PADI4,BRD1,SMARCB1A,MSL2,SMARCD1,ATF7IP,KAT6A,BRPF1,KDM4A |
| Cellular responses to stress | CHMP4C,SUZ12A,HIST2H3C,CBX8B,CDKN2B,DYNLL2B,HMGA1B,HSBP1A,NUPL2,C11orf73 |
| Chromatin organization | ATXN7,MBD3B,MSL2B,SMARCD3B,KAT6A,KDM4A,CHD4A,SMARCB1A,KDM5D,BRD8 |
| Oxidative Stress Induced Senescence | RING1,KDM6B,BMI1B,TNIK,MINK1,SUZ12A,CBX6A,BMI1A,SUZ12B,CBX8B |
| Epigenetic regulation of gene expression | EED,CD3EAP,SAP18,TET1,TAF1D,TAF1A,SIN3B,SAP30BP,MTF2,EFCAB11 |
Protein Function
SUZ12 has several biochemical functions, for example, RNA binding,RNA polymerase II core promoter sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUZ12 itself. We selected most functions SUZ12 had, and list some proteins which have the same functions with SUZ12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | GATA6,ZFP932,POU5F3,ARID3C,GATA4,RUNX2,LDB1,PRKAA1,HINFP,MLH3 |
| protein binding | ARL6IP1,STAT4,C1QTNF9,SNX32,IL10RA,TBL1X,DTNBP1,PML,CDK1,POLR2E |
| methylated histone binding | PHF1,CAPNS2,MPHOSPH8,L3MBTL2,TDRD3,MTF2,PHF19,CDYL2,RRP8,CBX4 |
| metal ion binding | ZNF766,PLD6,CYP2N13,TRIM41,MYLIPB,Reln,ZNF280B,RNASEH2A,GNAQ,SUCLA2 |
| RNA binding | RBM14,TUT1,RPL3,MBNL1,ZFP36L3,FAM120A,RBM4B,KHDC1A,MOV10B.2,RPL4 |
| histone methyltransferase activity | CARM1,PRDM13,PRMT1,EZH2,PRMT2,SUV39H1,PRMT6,EED |
| RNA polymerase II core promoter sequence-specific DNA binding | PAX8,H2AFZ,NFIL3,HOXB3,IRF7,YAP1,HNF4A,WBP2,MTF1,ZNF277 |
Interacting Protein
SUZ12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUZ12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUZ12.
EZH2;CUL4B
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References
- Lee, CH; Hoang, LN; et al. Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. MODERN PATHOLOGY 27:751-757(2014).
- Hattori, N; Niwa, T; et al. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. NUCLEIC ACIDS RESEARCH 41:7231-7239(2013).
