Recombinant Mouse Snx2 Protein, Myc/DDK-tagged

• Cat.No.: Snx2-6027M
• Product Overview: Purified recombinant protein of mouse full-length sorting nexin 2 (Snx2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 58.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Snx2 sorting nexin 2 [ Mus musculus (house mouse) ]
• Official Symbol: Snx2
• Synonyms: SNX2; sorting nexin 2; sorting nexin-2; 0610030A03Rik
• Gene ID: 67804
• mRNA Refseq: NM_026386
• Protein Refseq: NP_080662
• UniProt ID: Q9CWK8