Recombinant Mouse Smad6 Protein, Myc/DDK-tagged

• Cat.No.: Smad6-5953M
• Product Overview: Purified recombinant protein of mouse full-length SMAD family member 6 (Smad6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Binds to regulatory elements in target promoter regions. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 54.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Smad6 SMAD family member 6 [ Mus musculus (house mouse) ]
• Official Symbol: Smad6
• Synonyms: SMAD6; MAD homolog 6 (Drosophila); mothers against decapentaplegic homolog 6; Smad 6; mad homolog 7; SMAD family member 6; mothers against DPP homolog 6; Madh6
• Gene ID: 17130
• mRNA Refseq: NM_008542
• Protein Refseq: NP_032568
• UniProt ID: O35182