Recombinant Mouse Slc12a5 Protein, Myc/DDK-tagged

• Cat.No.: Slc12a5-5904M
• Product Overview: Purified recombinant protein of mouse full-length solute carrier family 12, member 5 (Slc12a5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
• Molecular Mass: 124 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Slc12a5 solute carrier family 12, member 5 [ Mus musculus (house mouse) ]
• Official Symbol: Slc12a5
• Synonyms: SLC12A5; solute carrier family 12, member 5; solute carrier family 12 member 5; mKCC2; K-Cl cotransporter 2; neuronal K-Cl cotransporter; electroneutral potassium-chloride cotransporter 2; KCC2; mKIAA1176
• Gene ID: 57138
• mRNA Refseq: NM_020333
• Protein Refseq: NP_065066
• UniProt ID: Q91V14