Recombinant Mouse Sgpl1 Protein, Myc/DDK-tagged

• Cat.No.: Sgpl1-5828M
• Product Overview: Purified recombinant protein of mouse full-length sphingosine phosphate lyase 1 (Sgpl1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 63.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sgpl1 sphingosine phosphate lyase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Sgpl1
• Synonyms: SGPL1; sphingosine phosphate lyase 1; sphingosine-1-phosphate lyase 1; mSPL; SPL 1; SP-lyase 1; sphingosine-1-phosphate aldolase; Spl; S1PL; AI428538; D10Xrf456
• Gene ID: 20397
• mRNA Refseq: NM_009163
• Protein Refseq: NP_033189
• UniProt ID: Q8R0X7