Recombinant Mouse Sfrp5 protein, His-tagged

• Cat.No.: Sfrp5-3487M
• Product Overview: Recombinant Mouse Sfrp5 protein(Q9WU66)(22-314aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 37.2 kDa
• Protein length: 22-314aa
• AA Sequence: APTRGQEYDYYGWQAEPLHGRSYSK PPQCLDIPADLPLCHTVGYKRMRLP NLLEHESLAEVKQQASSWLPLLAKR CHSDTQVFLCSLFAPVCLDRPIYPC RSLCEAARAGCAPLMEAYGFPWPEM LHCHKFPLDNDLCIAVQFGHLPATA PPVTKICAQCEMEHSADGLMEQMCS SDFVVKMRIKEIKIDNGDRKLIGAQ KKKKLLKAGPLKRKDTKKLVLHMKN GASCPCPQLDNLTGSFLVMGRKVEG QLLLTAVYRWDKKNKEMKFAVKFMF SYPCSLYYPFFYGAAEPH
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: Sfrp5 secreted frizzled-related sequence protein 5 [ Mus musculus ]
• Official Symbol: Sfrp5
• Synonyms: SFRP5; secreted frizzled-related sequence protein 5; secreted frizzled-related protein 5; sFRP-5; SARP3; AI605071
• Gene ID: 54612
• mRNA Refseq: NM_018780
• Protein Refseq: NP_061250

Reviews

05/20/2022

Satisfied customer—great product!

08/02/2019

Impressed with the quality control. This product is a gem in our lab experiments.

12/17/2018

Outstanding lab product!

Q&As

How is SFRP5 expression regulated at the transcriptional and post-transcriptional levels, and what factors influence its expression in different tissues?

SFRP5 expression is regulated by various factors, including transcriptional regulators and microRNAs. Tissue-specific expression is influenced by developmental cues and environmental signals.

Can you elaborate on the structural features of the SFRP5 protein and how they contribute to its interactions with Wnt ligands?

SFRP5 has a cysteine-rich domain that interacts with Wnt ligands, preventing their binding to Frizzled receptors. The structural configuration is crucial for modulating Wnt signaling.

Are there any identified genetic variations or polymorphisms in the SFRP5 gene, and how might they influence individual susceptibility to certain diseases?

Genetic variations in the SFRP5 gene have been identified, and certain polymorphisms are associated with altered susceptibility to diseases such as cancer and metabolic disorders.

How does SFRP5 contribute to tissue regeneration and repair, and what are the implications for regenerative medicine?

SFRP5 plays a role in tissue regeneration by modulating Wnt signaling during repair processes. Understanding its function contributes to the development of regenerative medicine strategies.

What are the implications of altered SFRP5 expression in diseases, particularly in conditions where dysregulated Wnt signaling is implicated?

Altered SFRP5 expression is associated with various diseases, including cancer and metabolic disorders, where dysregulated Wnt signaling plays a role in disease progression.