Recombinant Mouse Rd3 Protein, Myc/DDK-tagged

• Cat.No.: Rd3-5442M
• Product Overview: Purified recombinant protein of mouse full-length retinal degeneration 3 (Rd3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
• Molecular Mass: 22.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rd3 retinal degeneration 3 [ Mus musculus (house mouse) ]
• Official Symbol: Rd3
• Synonyms: RD3; retinal degeneration 3; protein RD3; rd3; rd-3; 3322402L07Rik; MGC117971; MGC151312; MGC151314
• Gene ID: 74023
• mRNA Refseq: NM_023727
• Protein Refseq: NP_076216
• UniProt ID: Q8BRE0