Recombinant Mouse Rangrf Protein, Myc/DDK-tagged

• Cat.No.: Rangrf-5371M
• Product Overview: Purified recombinant protein of mouse full-length RAN guanine nucleotide release factor (Rangrf), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
• Molecular Mass: 20.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rangrf RAN guanine nucleotide release factor [ Mus musculus (house mouse) ]
• Official Symbol: Rangrf
• Synonyms: RANGRF; RAN guanine nucleotide release factor; ran guanine nucleotide release factor; ran-binding protein MOG1; Mog1; Rangnrf; 2400006H24Rik; RP23-396M19.8; MGC107268
• Gene ID: 57785
• mRNA Refseq: NM_021329
• Protein Refseq: NP_067304
• UniProt ID: Q9JIB0