Recombinant Mouse Rab43 Protein, Myc/DDK-tagged

• Cat.No.: Rab43-5323M
• Product Overview: Purified recombinant protein of mouse full-length RAB43, member RAS oncogene family (Rab43), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 23.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rab43 RAB43, member RAS oncogene family [ Mus musculus (house mouse) ]
• Official Symbol: Rab43
• Synonyms: RAB43; RAB43, member RAS oncogene family; ras-related protein Rab-43; AW490415; MGC6993; 1810048P08Rik; 2500004H21Rik
• Gene ID: 69834
• mRNA Refseq: NM_001039394
• Protein Refseq: NP_001034483
• UniProt ID: Q8CG50