Recombinant Mouse Pclo Protein, His-tagged

• Cat.No.: Pclo-1925M
• Product Overview: Recombinant Mouse Pclo Protein (Leu4854-His5068) with N-His tag was expressed in E. coli.

Specification

• Description: Enables profilin binding activity. A structural constituent of presynaptic active zone. Involved in presynapse to nucleus signaling pathway; protein localization to synapse; and synaptic vesicle clustering. Acts upstream of or within cytoskeleton organization; insulin secretion; and regulation of exocytosis. Located in postsynaptic density and presynaptic active zone cytoplasmic component. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 27.6 kDa
  Accurate Molecular Mass: 33 kDa
• Protein length: Leu4854-His5068
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Pclo piccolo (presynaptic cytomatrix protein) [ Mus musculus (house mouse) ]
• Official Symbol: Pclo
• Synonyms: PCLO; piccolo (presynaptic cytomatrix protein); protein piccolo; aczonin; brain-derived HLMN protein; multidomain presynaptic cytomatrix protein; Acz; Pico; mKIAA0559
• Gene ID: 26875
• mRNA Refseq: NM_001110796
• Protein Refseq: NP_001104266
• UniProt ID: Q9QYX7