Recombinant Mouse Pan2 Protein, MYC/DDK-tagged
Cat.No. : | Pan2-224M |
Product Overview : | Purified recombinant protein of full-length mouse PAN2 poly(A) specific ribonuclease subunit (Pan2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Species : | Mouse |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. |
Molecular Mass : | 135.3 kDa |
Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ] |
Official Symbol | Pan2 |
Synonyms | Pan2; PAN2 poly(A) specific ribonuclease subunit; Usp52; AI047843; AW742773; mKIAA0710; 1200014O24Rik; PAN2-PAN3 deadenylation complex catalytic subunit Pan2; AN2 polyA specific ribonuclease subunit homolog; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2; PAN2 polyA specific ribonuclease subunit homolog; inactive ubiquitin carboxyl-terminal hydrolase 52; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; EC 3.1.13.4 |
Gene ID | 103135 |
mRNA Refseq | NM_133992 |
Protein Refseq | NP_598753 |
UniProt ID | Q8BGF7 |
◆ Recombinant Proteins | ||
PAN2-2165C | Recombinant Chicken PAN2 | +Inquiry |
PAN2-4265R | Recombinant Rat PAN2 Protein | +Inquiry |
PAN2-12331M | Recombinant Mouse PAN2 Protein | +Inquiry |
PAN2-6482M | Recombinant Mouse PAN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PAN2-3540H | Recombinant Human PAN2 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Cell & Tissue Lysates | ||
PAN2-3446HCL | Recombinant Human PAN2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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