PAN2
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Official Full Name
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) -
Overview
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3 to 5 exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. -
Synonyms
PAN2;PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae);ubiquitin specific peptidase 52 , ubiquitin specific protease 52 , USP52;PAB-dependent poly(A)-specific ribonuclease subunit 2;hPAN2;KIAA0710;PAN2 homolog;PABP1 dependent poly A specific ribonuclease subunit (S. cerevisiae);Inactive ubiquitin carboxyl terminal hydrolase 52;Inactive ubiquitin carboxyl-terminal hydrolase 52;PAB dependent poly(A) specific ribonuclease subunit 2;PABP dependent poly(A) nuclease 2;PAN 2;PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit;PAN2 poly(A) specific ribonuclease subunit homolog;PAN2 polyA specific ribonuclease subunit homolog;PAN2_HUMAN;Ubiquitin specific peptidase 52;Ubiquitin specific protease 52;USP 52;USP52;OTTHUMP00000243750;OTTHUMP00000243751;OTTHUMP00000243752;PABP-dependent poly(A) nuclease 2;PAN2 polyA specific ribonuclease subunit;inacti
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAN2-12331M | Recombinant Mouse PAN2 Protein | Mammalian Cells | Mouse | His |
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| PAN2-2165C | Recombinant Chicken PAN2 | Mammalian Cells | Chicken | His |
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| PAN2-4265R | Recombinant Rat PAN2 Protein | Mammalian Cells | Rat | His |
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| PAN2-3446HCL | Recombinant Human PAN2 293 Cell Lysate | HEK293 | Human | Non |
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| Pan2-224M | Recombinant Mouse Pan2 Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| PAN2-3540H | Recombinant Human PAN2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| PAN2-3927R | Recombinant Rat PAN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PAN2-3927R-B | Recombinant Rat PAN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PAN2-6482M | Recombinant Mouse PAN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PAN2-6482M-B | Recombinant Mouse PAN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PAN2 involved in several pathways and played different roles in them. We selected most pathways PAN2 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | CNOT4,EXOSC9,XRN2,CNOT10,PARN,LSM7,CNOT3A,LSM3,groL,PAPD7 |
Protein Function
PAN2 has several biochemical functions, for example, 3-5-exoribonuclease activity,nucleic acid binding,poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAN2 itself. We selected most functions PAN2 had, and list some proteins which have the same functions with PAN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5-exoribonuclease activity | DIS3,DIS3L,ERI3,C16orf57,CNOT8,SMFN,EXOSC5,EXOSC2,USB1,EXOSC4 |
| poly(A)-specific ribonuclease activity | TOE1,PDE12,CNOT7,CNOT8,CNOT6,CNOT6L,PARN |
| protein binding | NSMCE4A,C1orf38,TEX10,ZC3HC1,GGT1,SNIP1,CC2D1B,RPRD1A,KPNA3,PAX2 |
| nucleic acid binding | NPM1B,GTF3AA,GPATCH2,ZFP771,MTERFD3,ZFP503,ZNFL2A,EAR5,CPEB1B,PRDM7 |
Interacting Protein
PAN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAN2.
PAN3;ARCN1;VBP1;PLEC;TCEB1;TCEB2;TWF2;CBWD2;NUP93;CCT7;MRPL39;PFDN2;iutA;yubA;q81rg9_bacan
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References
- Nishii, Y; Yamaguchi, M; et al. A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1781-1787(2015).
- Inami, K; Kajino, K; et al. Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma. ONCOLOGY REPORTS 20:1375-1380(2008).
