Recombinant Mouse Nfasc Protein, Myc/DDK-tagged

• Cat.No.: Nfasc-4386M
• Product Overview: Purified recombinant protein of mouse full-length neurofascin (Nfasc), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
• Molecular Mass: 138.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nfasc neurofascin [ Mus musculus (house mouse) ]
• Official Symbol: Nfasc
• Synonyms: Nfasc; neurofascin; NF; AA387016; mKIAA0756; D430023G06Rik; neurofascin
• Gene ID: 269116
• mRNA Refseq: NM_182716
• Protein Refseq: NP_874385
• UniProt ID: Q810U3