NFASC
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Official Full Name
neurofascin -
Overview
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009] -
Synonyms
NFASC;neurofascin;NF;NRCAML;neurofascin homolog
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Human Cell
- HEK293T
- Wheat Germ
- His
- Non
- Myc&DDK
- Fc
- His&Fc&Avi
- GST
Involved Pathway
NFASC involved in several pathways and played different roles in them. We selected most pathways NFASC participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NFASC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CD22,PVR,CADM1A,CD28,MHC1UEA,MPZL1,HLA-DQA1,NEO1,CD40,JAM3 |
Protein Function
NFASC has several biochemical functions, for example, protein binding,protein binding involved in heterotypic cell-cell adhesion,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFASC itself. We selected most functions NFASC had, and list some proteins which have the same functions with NFASC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | NDE1,HIST1H4C,HMGB2,BASP1,CENPJ,SNCA,ACTN2,RAB27B,DICER1,ARHGEF4 |
| protein binding | PHF21A,CSNK1E,WNT2,HTR6,GNAI1,RTN1,BBS1,RUNDC3A,AK3,LRIF1 |
| protein binding involved in heterotypic cell-cell adhesion | NRCAM,GLDN |
Interacting Protein
NFASC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFASC here. Most of them are supplied by our site. Hope this information will be useful for your research of NFASC.
ABL1;FYN;NCK1;CRK;GRB2
Resources
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References
- Yan, WX; Nguyen, T; et al. Antibodies to neurofascin exacerbate adoptive transfer experimental autoimmune neuritis. JOURNAL OF NEUROIMMUNOLOGY 277:13-17(2014).
- Schulte-Mattler, WJ; et al. Immune-Mediated Neuropathies. KLINISCHE NEUROPHYSIOLOGIE 45:186-192(2014).
