Recombinant Mouse Myoc Protein, Myc/DDK-tagged

• Cat.No.: Myoc-4261M
• Product Overview: Purified recombinant protein of mouse full-length myocilin (Myoc), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 55.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Myoc myocilin [ Mus musculus (house mouse) ]
• Official Symbol: Myoc
• Synonyms: MYOC; myocilin; trabecular meshwork-induced glucocorticoid response protein; TIGR; GLC1A; AI957332; MGC159032
• Gene ID: 17926
• mRNA Refseq: NM_010865
• Protein Refseq: NP_034995
• UniProt ID: O70624