MYOC
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Official Full Name
myocilin, trabecular meshwork inducible glucocorticoid response -
Overview
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. -
Synonyms
MYOC;myocilin, trabecular meshwork inducible glucocorticoid response;GLC1A;myocilin;JOAG1;TIGR;mutated trabecular meshwork-induced glucocorticoid response protein;GPOA;JOAG
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Human Cell
- HEK293T
- Yeast
- Mammalian cells
- In Vitro Cell Free System
- Insect Cell
- His
- Non
- Myc&DDK
- His&Myc
- His&Fc&Avi
- Flag
- GST
Involved Pathway
MYOC involved in several pathways and played different roles in them. We selected most pathways MYOC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYOC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MYOC has several biochemical functions, for example, fibronectin binding,frizzled binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYOC itself. We selected most functions MYOC had, and list some proteins which have the same functions with MYOC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibronectin binding | ITGAV,FSTL3,MFAP2,LPA,ITGB3,ITGA3,ITGB1,ITGB1A,FBLN1,THBS1 |
| protein binding | HSPA4,MKRN2,CTCF,BRD7,STRN,RPAP3,HOMER2,PHF15,ALKBH4,SH2D3C |
| metal ion binding | NUBP2,VSNL1A,NUFIP1,INO80B,PPP6C,BTK,NSF,CAR15,ZNF354B,BMP1B |
| receptor tyrosine kinase binding | Flt3l,DOCK4,ARHGEF16,SQSTM1,PTPN1,SOCS5,PITPNM3,HYAL2,NRG1,TRP53 |
| frizzled binding | DVL1B,WNT2BB,WNT10B,WNT5B,WNT7A,WNT4A,WNT2,DVL3,WNT4,LRP6 |
| myosin light chain binding | MYO19,CXCR4,SPATA6 |
Interacting Protein
MYOC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYOC here. Most of them are supplied by our site. Hope this information will be useful for your research of MYOC.
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References
- Goldwich, A; Scholz, M; et al. Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells. HISTOCHEMISTRY AND CELL BIOLOGY 131:167-180(2009).
- Tawara, A; Tou, N; et al. Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 246:1021-1028(2008).
