Recombinant Mouse Mlkl protein, His-tagged

Cat.No. : MLKL-9880M
Product Overview : Recombinant Mouse Mlkl(1-472aa) fused with His tag was expressed in HEK293.
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Species : Mouse
Source : HEK293
Tag : His
Protein Length : 1-472aa
Description : This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
Form : Tris-based buffer,50% glycerol
Molecular Mass : 56.3kD
AA Sequence : MDKLGQIIKLGQLIYEQCEKMKYCRKQCQRLGNRVHGLLQPLQRLQAQGKKNLPDDITAALGRFDEVLKEANQQI EKFSKKSHIWKFVSVGNDKILFHEVNEKLRDVWEELLLLLQVYHWNTVSDVSQPASWQQEDRQDAEEDGNENMKV ILMQLQISVEEINKTLKQCSLKPTQEIPQDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQ AESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVL RAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGRS LSGRERILERLSAVEESTDKKV
Purity : >90% ( SDS-PAGE )
Storage : Store at -20 centigrade for extended storage conserve at -20 centigrade or -80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Gene Name Mlkl mixed lineage kinase domain-like [ Mus musculus ]
Official Symbol Mlkl
Synonyms MLKL; mixed lineage kinase domain-like; mixed lineage kinase domain-like protein; 9130019I15Rik;
Gene ID 74568
mRNA Refseq NM_029005
Protein Refseq NP_083281
MIM
UniProt ID Q9D2Y4
Chromosome Location 8; 8 D3
Function ATP binding; protein kinase activity; transferase activity, transferring phosphorus-containing groups;

Not For Human Consumption!

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