MLKL
-
Official Full Name
mixed lineage kinase domain-like -
Synonyms
MLKL;mixed lineage kinase domain-like;mixed lineage kinase domain-like protein;FLJ34389
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Insect Cells
- Yeast
- In Vitro Cell Free System
- GST
- His
- Non
- GST&His
- His&SUMO
Involved Pathway
MLKL involved in several pathways and played different roles in them. We selected most pathways MLKL participated on our site, such as DNA damage response (only ATM dependent),Programmed Cell Death,RIPK1-mediated regulated necrosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response (only ATM dependent) | DVL2,DVL1,DVL3,BIK |
| Programmed Cell Death | DSG2,HMGB2,BAXB,GAS2,ADD1,DSG3,STK24A,BMX,GZME,DIABLOA |
| TNF signaling pathway | IL6,PIK3CD,CREB5,CASP8,PIK3R3,CXCL5,IL1B,CASP7,TNFRSF1B,TRAF3 |
Protein Function
MLKL has several biochemical functions, for example, ATP binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLKL itself. We selected most functions MLKL had, and list some proteins which have the same functions with MLKL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCA4A,DNAJA1,CTPS2,GRK7B,MAP2K1,TSSK2,KIF19,DNAJA3B,TNIK,ATM |
| protein kinase binding | CDC42,STX1B,FAM83B,CCNK,ITGB2,VRK1,PRKAB1,NBEA,LSM2,GYS1 |
| protein complex binding | SHANK1,SIX2,NOG,SKIL,UFD1L,ANKRD32,C8G,ITGB1BP1,CD2AP,HSPD1 |
| NOT protein kinase activity | TRIB2,STRADB,TRIB1,STRADA,PXK,HSPB8 |
| protein binding | SNRPA1,DIAP1,LSAMP,PHOSPHO2,KIR2DL3,SIPA1L2,RNF34,ACE2,ADAMTS3,ASTE1 |
| protein serine/threonine kinase activity | MARK2,LATS1,BMPR1A,PIM1,VRK2,DSTYK,TGFBR1,OXSR1B,BUB1B,RIPK2 |
Interacting Protein
MLKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLKL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLKL.
RIPK3;necrosulfonamide;PITPNA;CDK1;NDUFB7;THOC3;RAD18;ANAPC11
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