Recombinant Mouse Mark3 Protein, Myc/DDK-tagged

• Cat.No.: Mark3-3961M
• Product Overview: Purified recombinant protein of mouse full-length MAP/microtubule affinity-regulating kinase 3 (cDNA clone MGC:31426 IMAGE:4459439), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 47.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mark3 MAP/microtubule affinity regulating kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Mark3
• Synonyms: Mark3; MAP/microtubule affinity regulating kinase 3; ETK1; Emk2; C-TAK; ETK-1; MPK10; C-TAK1; 1600015G02Rik; A430080F22Rik; MAP/microtubule affinity-regulating kinase 3; ELKL motif kinase 2; EMK-2; EMK2/MARK3 serine-threonine protein kinase; MPK-10; EC 2.7.11.1
• Gene ID: 17169
• mRNA Refseq: NM_022801
• Protein Refseq: NP_073712
• UniProt ID: Q03141